Candida-Associated Urinary Tract Infections in Children: A Single-Center Experience

ABDULLAH AKKUŞ

doi:10.56752/Mevmedsci.2025.79

ABDULLAH AKKUŞ, ÖZGE METİN AKÇAN, METİN DOĞAN, Mustafa GENÇELİ, Kübra Nur Erdoğan, arif, Sipil Gençeli

Year : 2025
Vol : 1
Issue : 5
Page : 1-4

DOI : 10.56752/Mevmedsci.2025.79

Introduction: The incidence of fungal infections, particularly those caused by Candida species, has been increasing globally. These infections are especially prevalent in nosocomial settings, affecting patients with predisposing conditions such as chronic illness, recent invasive procedures, admission to intensive care units (ICUs), and exposure to broad-spectrum antibiotics. This study aims to characterize the clinical presentation, laboratory findings, and risk factors associated with candiduria in a pediatric population. Materials and Methods: This retrospective study analyzed data from pediatric patients aged 1 month to 18 years diagnosed with candiduria at our institution between January 2017 and June 2024. Results: The study cohort comprised 58 pediatric patients (22 females, 36 males) with confirmed Candida species isolated from urine cultures. The mean age was 6.2 ± 2.9 years. Candida albicans was the most prevalent species, identified in 43 (74.1%) patients, followed by C. parapsilosis (13.7%), C. tropicalis (6.8%), C. lusitaniae (1.7%), C. lipolytica (1.7%), and C. krusei (1.7%). Clinical manifestations during candiduria episodes included fever (55.1%), dysuria (46.5%), flank pain (15.5%), suprapubic tenderness (13.7%), urinary frequency (12%), and urgency (6.8%). The most frequently observed risk factors among these patients were urinary catheterization (63.7%), ICU admission (60.3%), prolonged antibiotic use (58.6%), and the presence of a central venous catheter (56.8%). Laboratory findings revealed a mean leukocyte count of 12,964 ± 8,448/mm³, a neutrophil count of 8,297 ± 6,495/mm³, a urea level of 29.3 ± 26.3 mg/dL, a creatinine level of 0.49 ± 0.29 mg/dL, and a C-reactive protein level of 34.2 ± 25.3 mg/L. Antifungal therapy consisted of fluconazole in 57 patients and caspofungin in 1 patient. Conclusion: Effective management of candiduria requires a thorough understanding of local epidemiological trends and patient-specific risk factors. In pediatric patients, candiduria, particularly when accompanied by multiple risk factors, necessitates careful clinical evaluation and tailored treatment strategies.

Cite this Article As : Genceli M, Erdogan AC, Erdogan KN, Genceli S, Akkus A, Akcan Metin O, Dogan M. Candida-Associated Urinary Tract Infections in Children: A Single-Center Experience. Mev Med Sci. 2025; 5(1): 1-4

Description : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.

Candida-Associated Urinary Tract Infections in Children: A Single-Center Experience, Research Article,
2025, Vol. 1 (5)

Received : 19.12.2024, Accepted : 18.03.2025 , Published Online : 18.04.2025