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Occurrence of hematological diseases in patients with intraabdominal venous thrombosis and evaluation of PNH

Occurrence of hematological diseases in patients with intraabdominal venous thrombosis and evaluation of PNH

Kübra Yel Uygun, Ali Erkan Duman, Şule Poturoğlu, Mesut Ayer

  •  Year : 2025
  •  Vol : 1
  •  Issue : 5
  •  Page : 11-17
Introduction: This study aims to describe the clinical, demographic, and laboratory characteristics of patients with abdominal venous thrombosis (AVT) and investigate the presence of paroxysmal nocturnal hemoglobinuria (PNH) clones. AVT is a rare but significant condition that affects various anatomical regions, including portal vein thrombosis (PVT), renal vein thrombosis (RVT), mesenteric vein thrombosis (MVT), and splenic vein thrombosis (SVT). Understanding the role of hematological diseases, including PNH, in the development of AVT may provide insight into its underlying mechanisms. Method: This retrospective case series was conducted at a tertiary research hospital. The study cohort consisted of adult patients diagnosed with and treated for intra-abdominal venous thrombosis. Data were collected from hospital information management system records. Demographic and clinical variables such as age, sex, thrombosis location, comorbidities, prothrombotic conditions, and genetic mutations were recorded. PNH clone presence was assessed for each patient using flow cytometry. Results: Data from 32 patients were analyzed. The mean age was 45 ± 15.6 years. Isolated PVT was observed in 21 patients (65.6%), while 4 (12.5%) had both PVT and RVT. MVT was observed in 1 patient (3.1%), and SVT in 2 patients (6.3%). Of the 3 patients with Budd-Chiari syndrome, 2 had SVT. Comorbidities included cirrhosis (6 patients), polycythemia vera (1), Factor V Leiden mutation (1), and protein C deficiency (2). No patient had a prior history of malignancy. Conclusion: There was no significant difference between male and female patients regarding risk factors, comorbidities, and multi-vessel thrombosis. No PNH clones were detected in any patient, suggesting a limited role for PNH in AVT pathogenesis. Further studies with larger cohorts are required to confirm these findings.
Cite this Article As : Yel Uygun K, Duman AE, Poturoglu S, Ayer M. Occurrence of hematological diseases in patients with intraabdominal venous thrombosis and evaluation of PNH. Mev Med Sci. 2025; 5(1): 11-17

Description : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Occurrence of hematological diseases in patients with intraabdominal venous thrombosis and evaluation of PNH, Research Article,
, Vol. 1 (5)
Received : 11.12.2024, Accepted : 17.02.2025 , Published Online : 18.04.2025
Mevlana Tıp Bilimleri
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E-ISSN: 2757-976X ;
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