The Prognostic Significance of The Ionized Calcium Value Measured at Admission in Patients With Sepsis in The Emergency Intensive Care Unit

MUSTAFA KÜRŞAT AYRANCI

doi:10.56752/Mevmedsci.2025.94

MUSTAFA KÜRŞAT AYRANCI, AHMET ÇAK, SAMİ ATAMAN

Year : 2025
Vol : 5
Issue : 3
Page : 79-87

DOI : 10.56752/Mevmedsci.2025.94

Objective Calcium plays an important role in almost all cellular processes. Measurement of ionized calcium levels is more important in demonstrating calcium metabolism. Tight control of calcium metabolism is impaired during sepsis. However, the prognostic significance of ionized calcium levels in patients admitted to the intensive care unit (ICU) due to sepsis is not fully known. The aim of our study was to evaluate the prognostic significance of ionized calcium levels in patients admitted to the ICU due to sepsis. Material and methods A total of 228 patients who were admitted to the emergency department of the university Faculty of Medicine and admitted to the emergency ICU with a diagnosis of sepsis between January 2020 and December 2021 were included in the study. Demographic characteristics, vital signs, Sequential Organ Failure Assessment (SOFA), Rapid Sequential Organ Failure Assessment (qSOFA), ionized calcium and total serum calcium levels, blood gas, hemogram and biochemistry parameters, hospital outcome, and 7-day mortality status were retrospectively screened and analyzed. Results The mean ionized calcium level of the cases was 1.07 ± 0.20 mmol/L, and the albumin-corrected calcium level was 9.20 ± 1.06 mg/dL. While the 7-day mortality rate was 25.4%, the hospital mortality rate was up to 57.9%. ROC analyses showed that ionized calcium concentrations were not the sole predictors of 7-day mortality (AUC=0.561, 95% CI 0.494-0.626, p=0.188) and hospital outcome (AUC=0.525, 95% CI 0.458-0.591, p=0.517). Ionized calcium levels were also not correlated with SOFA score, ICU length of stay, and hospital length of stay, which were significant predictors of mortality. Conclusion Ionized calcium may provide more accurate information than corrected total serum calcium levels in determining calcium levels. The frequency of hypocalcemia is quite high in sepsis cases. However, the prognostic value of ionized calcium is limited in patients admitted to the ICU due to sepsis.

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Description : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.

The Prognostic Significance of The Ionized Calcium Value Measured at Admission in Patients With Sepsis in The Emergency Intensive Care Unit, Research Article,
2025, Vol. 5 (3)

Received : 07.05.2025, Accepted : 28.07.2025 , Published Online : 12.12.2025